Separation of Sedative – Hypnotic Drugs with Mixed Micellar Liquid Chromatography
نویسندگان
چکیده مقاله:
Separation of ten sedative- hypnotic drugs was performed by RP-HPLC using mixed micellar mobile phase. Effect of temperature, type and amount of organic modifier in mobile phase on efficiency (N) and asymmetry factor (B/A) showed that, the appropriate conditions for a good separation were 35°C and 7% (V/V) butanol in mobile phase. Variations of selectivity factor versus butanol concentration, Mixture of SDS/ Brij- 35 concentrations and pH of mobile phase showed that the appropriate conditions were 7%(V/V), 15 mM SDS +1.0mM Brij-35 and pH=3 in mobile phase respectively.
منابع مشابه
separation of sedative – hypnotic drugs with mixed micellar liquid chromatography
separation of ten sedative- hypnotic drugs was performed by rp-hplc using mixed micellar mobile phase. effect of temperature, type and amount of organic modifier in mobile phase on efficiency (n) and asymmetry factor (b/a) showed that, the appropriate conditions for a good separation were 35°c and 7% (v/v) butanol in mobile phase. variations of selectivity factor versus butanol concentration, ...
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عنوان ژورنال
دوره 24 شماره 2
صفحات 59- 63
تاریخ انتشار 2005-06-01
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